To "Grow" or "Go": TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN
Identifieur interne : 004D80 ( Main/Exploration ); précédent : 004D79; suivant : 004D81To "Grow" or "Go": TMEM16A Expression as a Switch between Tumor Growth and Metastasis in SCCHN
Auteurs : Daniel J. Shiwarski [États-Unis] ; CHUNBO SHAO [États-Unis] ; Anke Bill [États-Unis] ; Jean Kim [États-Unis] ; DONG XIAO [États-Unis] ; Carol A. Bertrand [États-Unis] ; Raja S. Seethala [États-Unis] ; Daisuke Sano [Japon] ; Jeffery N. Myers [États-Unis] ; Patrick Ha [États-Unis] ; Jennifer Grandis [États-Unis] ; L. Alex Gaither [États-Unis] ; Manojkumar A. Puthenveedu [États-Unis] ; Umamaheswar Duvvuri [États-Unis]Source :
- Clinical cancer research : (Print) [ 1078-0432 ] ; 2014.
Descripteurs français
- KwdFr :
- Animaux, Canaux chlorure (biosynthèse), Canaux chlorure (génétique), Carcinogenèse (génétique), Carcinome épidermoïde (anatomopathologie), Carcinome épidermoïde (génétique), Humains, Lignée cellulaire tumorale, Mouvement cellulaire (génétique), Métastase lymphatique (génétique), Méthylation de l'ADN (génétique), Prolifération cellulaire (génétique), Protéines du cytosquelette (génétique), Protéines membranaires (génétique), Protéines tumorales (biosynthèse), Protéines tumorales (génétique), Régulation de l'expression des gènes tumoraux, Souris, Tests d'activité antitumorale sur modèle de xénogreffe, Transition épithélio-mésenchymateuse (génétique), Tumeurs de la tête et du cou (anatomopathologie), Tumeurs de la tête et du cou (génétique).
- MESH :
- anatomopathologie : Carcinome épidermoïde, Tumeurs de la tête et du cou.
- biosynthèse : Canaux chlorure, Protéines tumorales.
- génétique : Canaux chlorure, Carcinogenèse, Carcinome épidermoïde, Mouvement cellulaire, Métastase lymphatique, Méthylation de l'ADN, Prolifération cellulaire, Protéines du cytosquelette, Protéines membranaires, Protéines tumorales, Transition épithélio-mésenchymateuse, Tumeurs de la tête et du cou.
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Carcinogenesis (genetics), Carcinoma, Squamous Cell (genetics), Carcinoma, Squamous Cell (pathology), Cell Line, Tumor, Cell Movement (genetics), Cell Proliferation (genetics), Chloride Channels (biosynthesis), Chloride Channels (genetics), Cytoskeletal Proteins (genetics), DNA Methylation (genetics), Epithelial-Mesenchymal Transition (genetics), Gene Expression Regulation, Neoplastic, Gene expression, Head and Neck Neoplasms (genetics), Head and Neck Neoplasms (pathology), Humans, Lymphatic Metastasis (genetics), Malignant tumor, Membrane Proteins (genetics), Metastasis, Mice, Neoplasm Proteins (biosynthesis), Neoplasm Proteins (genetics), Tumor growth, Xenograft Model Antitumor Assays.
- MESH :
- chemical , biosynthesis : Chloride Channels, Neoplasm Proteins.
- genetics : Carcinogenesis, Carcinoma, Squamous Cell, Cell Movement, Cell Proliferation, Chloride Channels, Cytoskeletal Proteins, DNA Methylation, Epithelial-Mesenchymal Transition, Head and Neck Neoplasms, Lymphatic Metastasis, Membrane Proteins, Neoplasm Proteins.
- pathology : Carcinoma, Squamous Cell, Head and Neck Neoplasms.
- Animals, Cell Line, Tumor, Gene Expression Regulation, Neoplastic, Humans, Mice, Xenograft Model Antitumor Assays.
Abstract
Purpose: Tumor metastasis is the leading cause of death in patients with cancer. However, the mechanisms that underlie metastatic progression remain unclear. We examined TMEM16A (ANO1) expression as a key factor shifting tumors between growth and metastasis. Experimental Design: We evaluated 26 pairs of primary and metastatic lymph node (LN) tissue from patients with squamous cell carcinoma of the head and neck (SCCHN) for differential expression of TMEM16A. In addition, we identified mechanisms by which TMEM16A expression influences tumor cell motility via proteomic screens of cell lines and in vivo mouse studies of metastasis. Results: Compared with primary tumors, TMEM16A expression decreases in metastatic LNs of patients with SCCHN. Stable reduction of TMEM16A expression enhances cell motility and increases metastases while decreasing tumor proliferation in an orthotopic mouse model. Evaluation of human tumor tissues suggests an epigenetic mechanism for decreasing TMEM16A expression through promoter methylation that correlated with a transition between an epithelial and a mesenchymal phenotype. These effects of TMEM16A expression on tumor cell size and epithelial-to-mesenchymal transition (EMT) required the amino acid residue serine 970 (S970); however, mutation of S970 to alanine does not disrupt the proliferative advantages of TMEM16A overexpression. Furthermore, S970 mediates the association of TMEM16A with Radixin, an actin-scaffolding protein implicated in EMT. Conclusions: Together, our results identify TMEM16A, an eight transmembrane domain Ca2+-activated Cl- channel, as a primary driver of the "Grow" or "Go" model for cancer progression, in which TMEM16A expression acts to balance tumor proliferation and metastasis via its promoter methylation.
Url:
Affiliations:
- Japon, États-Unis
- Maryland, Massachusetts, Pennsylvanie, Texas
- Pittsburgh
- Université Carnegie-Mellon, Université de Pittsburgh
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Le document en format XML
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Shiwarski</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>VA Pittsburgh Health System</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Otolaryngology, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Biological Sciences, Carnegie Mellon University</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université Carnegie-Mellon</orgName></affiliation></author><author><name sortKey="Chunbo Shao" sort="Chunbo Shao" uniqKey="Chunbo Shao" last="Chunbo Shao">CHUNBO SHAO</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Otolaryngology, Johns Hopkins University School of Medicine</s1><s2>Baltimore, Maryland</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Bill, Anke" sort="Bill, Anke" uniqKey="Bill A" first="Anke" last="Bill">Anke Bill</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Developmental and Molecular Pathways, Novartis Institute for Biomedical Research Inc</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Kim, Jean" sort="Kim, Jean" uniqKey="Kim J" first="Jean" last="Kim">Jean Kim</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>VA Pittsburgh Health System</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Otolaryngology, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Dong Xiao" sort="Dong Xiao" uniqKey="Dong Xiao" last="Dong Xiao">DONG XIAO</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>VA Pittsburgh Health System</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Otolaryngology, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Bertrand, Carol A" sort="Bertrand, Carol A" uniqKey="Bertrand C" first="Carol A." last="Bertrand">Carol A. Bertrand</name><affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Department of Cell Biology, University of Pittsburgh Medical Center</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Seethala, Raja S" sort="Seethala, Raja S" uniqKey="Seethala R" first="Raja S." last="Seethala">Raja S. Seethala</name><affiliation wicri:level="2"><inist:fA14 i1="07"><s1>Department of Pathology, University of Pittsburgh Medical Center</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>7 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Sano, Daisuke" sort="Sano, Daisuke" uniqKey="Sano D" first="Daisuke" last="Sano">Daisuke Sano</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Yokohama City University, School of Medicine</s1><s2>Yokohama</s2><s3>JPN</s3><sZ>8 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Yokohama</wicri:noRegion></affiliation></author><author><name sortKey="Myers, Jeffery N" sort="Myers, Jeffery N" uniqKey="Myers J" first="Jeffery N." last="Myers">Jeffery N. Myers</name><affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center</s1><s2>Houston, Texas</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Ha, Patrick" sort="Ha, Patrick" uniqKey="Ha P" first="Patrick" last="Ha">Patrick Ha</name><affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Department of Otolaryngology, Johns Hopkins University School of Medicine</s1><s2>Baltimore, Maryland</s2><s3>USA</s3><sZ>2 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Maryland</region></placeName></affiliation></author><author><name sortKey="Grandis, Jennifer" sort="Grandis, Jennifer" uniqKey="Grandis J" first="Jennifer" last="Grandis">Jennifer Grandis</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>VA Pittsburgh Health System</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Otolaryngology, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Gaither, L Alex" sort="Gaither, L Alex" uniqKey="Gaither L" first="L. Alex" last="Gaither">L. Alex Gaither</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Department of Developmental and Molecular Pathways, Novartis Institute for Biomedical Research Inc</s1><s2>Cambridge, Massachusetts</s2><s3>USA</s3><sZ>3 aut.</sZ><sZ>12 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Puthenveedu, Manojkumar A" sort="Puthenveedu, Manojkumar A" uniqKey="Puthenveedu M" first="Manojkumar A." last="Puthenveedu">Manojkumar A. Puthenveedu</name><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Department of Biological Sciences, Carnegie Mellon University</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université Carnegie-Mellon</orgName></affiliation></author><author><name sortKey="Duvvuri, Umamaheswar" sort="Duvvuri, Umamaheswar" uniqKey="Duvvuri U" first="Umamaheswar" last="Duvvuri">Umamaheswar Duvvuri</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>VA Pittsburgh Health System</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Otolaryngology, University of Pittsburgh</s1><s2>Pittsburgh, Pennsylvania</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>11 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author></analytic><series><title level="j" type="main">Clinical cancer research : (Print)</title><title level="j" type="abbreviated">Clin. cancer res. : (Print)</title><idno type="ISSN">1078-0432</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical cancer research : (Print)</title><title level="j" type="abbreviated">Clin. cancer res. : (Print)</title><idno type="ISSN">1078-0432</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Carcinogenesis (genetics)</term><term>Carcinoma, Squamous Cell (genetics)</term><term>Carcinoma, Squamous Cell (pathology)</term><term>Cell Line, Tumor</term><term>Cell Movement (genetics)</term><term>Cell Proliferation (genetics)</term><term>Chloride Channels (biosynthesis)</term><term>Chloride Channels (genetics)</term><term>Cytoskeletal Proteins (genetics)</term><term>DNA Methylation (genetics)</term><term>Epithelial-Mesenchymal Transition (genetics)</term><term>Gene Expression Regulation, Neoplastic</term><term>Gene expression</term><term>Head and Neck Neoplasms (genetics)</term><term>Head and Neck Neoplasms (pathology)</term><term>Humans</term><term>Lymphatic Metastasis (genetics)</term><term>Malignant tumor</term><term>Membrane Proteins (genetics)</term><term>Metastasis</term><term>Mice</term><term>Neoplasm Proteins (biosynthesis)</term><term>Neoplasm Proteins (genetics)</term><term>Tumor growth</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Canaux chlorure (biosynthèse)</term><term>Canaux chlorure (génétique)</term><term>Carcinogenèse (génétique)</term><term>Carcinome épidermoïde (anatomopathologie)</term><term>Carcinome épidermoïde (génétique)</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Mouvement cellulaire (génétique)</term><term>Métastase lymphatique (génétique)</term><term>Méthylation de l'ADN (génétique)</term><term>Prolifération cellulaire (génétique)</term><term>Protéines du cytosquelette (génétique)</term><term>Protéines membranaires (génétique)</term><term>Protéines tumorales (biosynthèse)</term><term>Protéines tumorales (génétique)</term><term>Régulation de l'expression des gènes tumoraux</term><term>Souris</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Transition épithélio-mésenchymateuse (génétique)</term><term>Tumeurs de la tête et du cou (anatomopathologie)</term><term>Tumeurs de la tête et du cou (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Chloride Channels</term><term>Neoplasm Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Carcinome épidermoïde</term><term>Tumeurs de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Canaux chlorure</term><term>Protéines tumorales</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Carcinogenesis</term><term>Carcinoma, Squamous Cell</term><term>Cell Movement</term><term>Cell Proliferation</term><term>Chloride Channels</term><term>Cytoskeletal Proteins</term><term>DNA Methylation</term><term>Epithelial-Mesenchymal Transition</term><term>Head and Neck Neoplasms</term><term>Lymphatic Metastasis</term><term>Membrane Proteins</term><term>Neoplasm Proteins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Canaux chlorure</term><term>Carcinogenèse</term><term>Carcinome épidermoïde</term><term>Mouvement cellulaire</term><term>Métastase lymphatique</term><term>Méthylation de l'ADN</term><term>Prolifération cellulaire</term><term>Protéines du cytosquelette</term><term>Protéines membranaires</term><term>Protéines tumorales</term><term>Transition épithélio-mésenchymateuse</term><term>Tumeurs de la tête et du cou</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Carcinoma, Squamous Cell</term><term>Head and Neck Neoplasms</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line, Tumor</term><term>Gene Expression Regulation, Neoplastic</term><term>Humans</term><term>Mice</term><term>Xenograft Model Antitumor Assays</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Expression génique</term><term>Humains</term><term>Lignée cellulaire tumorale</term><term>Régulation de l'expression des gènes tumoraux</term><term>Souris</term><term>Tests d'activité antitumorale sur modèle de xénogreffe</term><term>Tumeur maligne</term><term>Croissance tumorale</term><term>Métastase</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Purpose: Tumor metastasis is the leading cause of death in patients with cancer. However, the mechanisms that underlie metastatic progression remain unclear. We examined TMEM16A (ANO1) expression as a key factor shifting tumors between growth and metastasis. Experimental Design: We evaluated 26 pairs of primary and metastatic lymph node (LN) tissue from patients with squamous cell carcinoma of the head and neck (SCCHN) for differential expression of TMEM16A. In addition, we identified mechanisms by which TMEM16A expression influences tumor cell motility via proteomic screens of cell lines and in vivo mouse studies of metastasis. Results: Compared with primary tumors, TMEM16A expression decreases in metastatic LNs of patients with SCCHN. Stable reduction of TMEM16A expression enhances cell motility and increases metastases while decreasing tumor proliferation in an orthotopic mouse model. Evaluation of human tumor tissues suggests an epigenetic mechanism for decreasing TMEM16A expression through promoter methylation that correlated with a transition between an epithelial and a mesenchymal phenotype. These effects of TMEM16A expression on tumor cell size and epithelial-to-mesenchymal transition (EMT) required the amino acid residue serine 970 (S970); however, mutation of S970 to alanine does not disrupt the proliferative advantages of TMEM16A overexpression. Furthermore, S970 mediates the association of TMEM16A with Radixin, an actin-scaffolding protein implicated in EMT. Conclusions: Together, our results identify TMEM16A, an eight transmembrane domain Ca<sup>2+</sup>-activated Cl<sup>-</sup> channel, as a primary driver of the "Grow" or "Go" model for cancer progression, in which TMEM16A expression acts to balance tumor proliferation and metastasis via its promoter methylation.</div></front></TEI><affiliations><list><country><li>Japon</li><li>États-Unis</li></country><region><li>Maryland</li><li>Massachusetts</li><li>Pennsylvanie</li><li>Texas</li></region><settlement><li>Pittsburgh</li></settlement><orgName><li>Université Carnegie-Mellon</li><li>Université de Pittsburgh</li></orgName></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Shiwarski, Daniel J" sort="Shiwarski, Daniel J" uniqKey="Shiwarski D" first="Daniel J." last="Shiwarski">Daniel J. Shiwarski</name></region><name sortKey="Bertrand, Carol A" sort="Bertrand, Carol A" uniqKey="Bertrand C" first="Carol A." last="Bertrand">Carol A. Bertrand</name><name sortKey="Bill, Anke" sort="Bill, Anke" uniqKey="Bill A" first="Anke" last="Bill">Anke Bill</name><name sortKey="Chunbo Shao" sort="Chunbo Shao" uniqKey="Chunbo Shao" last="Chunbo Shao">CHUNBO SHAO</name><name sortKey="Dong Xiao" sort="Dong Xiao" uniqKey="Dong Xiao" last="Dong Xiao">DONG XIAO</name><name sortKey="Dong Xiao" sort="Dong Xiao" uniqKey="Dong Xiao" last="Dong Xiao">DONG XIAO</name><name sortKey="Duvvuri, Umamaheswar" sort="Duvvuri, Umamaheswar" uniqKey="Duvvuri U" first="Umamaheswar" last="Duvvuri">Umamaheswar Duvvuri</name><name sortKey="Duvvuri, Umamaheswar" sort="Duvvuri, Umamaheswar" uniqKey="Duvvuri U" first="Umamaheswar" last="Duvvuri">Umamaheswar Duvvuri</name><name sortKey="Gaither, L Alex" sort="Gaither, L Alex" uniqKey="Gaither L" first="L. Alex" last="Gaither">L. Alex Gaither</name><name sortKey="Grandis, Jennifer" sort="Grandis, Jennifer" uniqKey="Grandis J" first="Jennifer" last="Grandis">Jennifer Grandis</name><name sortKey="Grandis, Jennifer" sort="Grandis, Jennifer" uniqKey="Grandis J" first="Jennifer" last="Grandis">Jennifer Grandis</name><name sortKey="Ha, Patrick" sort="Ha, Patrick" uniqKey="Ha P" first="Patrick" last="Ha">Patrick Ha</name><name sortKey="Kim, Jean" sort="Kim, Jean" uniqKey="Kim J" first="Jean" last="Kim">Jean Kim</name><name sortKey="Kim, Jean" sort="Kim, Jean" uniqKey="Kim J" first="Jean" last="Kim">Jean Kim</name><name sortKey="Myers, Jeffery N" sort="Myers, Jeffery N" uniqKey="Myers J" first="Jeffery N." last="Myers">Jeffery N. Myers</name><name sortKey="Puthenveedu, Manojkumar A" sort="Puthenveedu, Manojkumar A" uniqKey="Puthenveedu M" first="Manojkumar A." last="Puthenveedu">Manojkumar A. Puthenveedu</name><name sortKey="Seethala, Raja S" sort="Seethala, Raja S" uniqKey="Seethala R" first="Raja S." last="Seethala">Raja S. Seethala</name><name sortKey="Shiwarski, Daniel J" sort="Shiwarski, Daniel J" uniqKey="Shiwarski D" first="Daniel J." last="Shiwarski">Daniel J. Shiwarski</name><name sortKey="Shiwarski, Daniel J" sort="Shiwarski, Daniel J" uniqKey="Shiwarski D" first="Daniel J." last="Shiwarski">Daniel J. Shiwarski</name></country><country name="Japon"><noRegion><name sortKey="Sano, Daisuke" sort="Sano, Daisuke" uniqKey="Sano D" first="Daisuke" last="Sano">Daisuke Sano</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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